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208R-1 Sigma-Aldrich

GH (EP267) Rabbit Monoclonal Primary Antibody

  •  NACRES NA.41

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Properties

Related Categories Antibodies, Cell Marque Antibodies, Neuropathology, Primary Antibodies
Quality Level   100
  500
biological source   rabbit
antibody form   culture supernatant
antibody product type   primary antibodies
clone   EP267, monoclonal
description   (For In Vitro Diagnostic Use in Select Regions (See Chart))
form   buffered aqueous solution
species reactivity   human
packaging   bottle of 1.0 mL predilute (208R-17)
  bottle of 7.0 mL predilute (208R-18)
  vial of 0.1 mL concentrate (208R-14)
  vial of 0.5 mL concentrate (208R-15)
  vial of 1.0 mL concentrate (208R-16)
mfr. no.   Cell Marque
concentration   0.01-1.0 μg/ml (predilute)
  1-100 ug/ml (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype   IgG
conjugate   unconjugated
shipped in   wet ice
storage temp.   2-8°C

Description

General description

Pituitary growth hormone (GH) plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GH is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone contains 191 amino acid residues with two disulfide bridges. Anti-GH is a useful marker in classification of pituitary tumors and the study of pituitary disease (acromegaly).1-3 It reacts with GH-producing cells. Growth hormone receptors have been found in various non-pituitary cells, including that from hepatocellular carcinoma and various benign and malignant cutaneous lesions.4-6

Quality


IVD

IVD

IVD

RUO

Linkage

GH Positive Control Slides, Product No. 208S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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