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213942 Sigma-Aldrich

3-Methylcholanthrene

98%

  • CAS Number 56-49-5

  • Empirical Formula (Hill Notation) C21H16

  • Molecular Weight 268.35

  •  Beilstein/REAXYS Number 1913890

  •  EC Number 200-276-4

  •  MDL number MFCD00003704

  •  PubChem Substance ID 57647926

  •  NACRES NA.25

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Properties

Related Categories Cancer Research, Carcinogens, Cell Biology More...
Quality Level   200
assay   98%
bp   280 °C/80 mmHg (lit.)
mp   178-180 °C (lit.)
SMILES string   Cc1ccc2cc3c(ccc4ccccc34)c5CCc1c25
InChI   1S/C21H16/c1-13-6-7-15-12-20-17-5-3-2-4-14(17)8-9-18(20)19-11-10-16(13)21(15)19/h2-9,12H,10-11H2,1H3
InChI key   PPQNQXQZIWHJRB-UHFFFAOYSA-N

Description

Application

3-Methylcholanthrene has been used to assess its tumor initiation activity by Bhas 42 cell transformation assay. It has also been used to induce the activity of cytochrome P450.

Packaging

100, 250 mg in glass bottle

Biochem/physiol Actions

3-Methylcholanthrene is a carcinogen used to induce transformation of cultured cells. It is also used to induce fibrosarcomas and skin carcinomas in laboratory animals. 3-methylcholanthrene is a potent aryl hydrocarbon receptor agonist.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
WGK Germany 
WGK 3
RTECS 
FZ3675000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

US EPA Method 8100: GC Analysis of Polynuclear Aromatic Hydrocarbons (PAHs) on SLB®-5ms

From our library of Articles, Sigma-Aldrich presents US EPA Method 8100: GC Analysis of Polynuclear Aromatic Hydrocarbons (PAHs) on SLB®-5ms
Keywords: Chromatography, Gas chromatography, Purification

US EPA Method 8100: GC Analysis of Polynuclear Aromatic Hydrocarbons (PAHs) on SPB®-608

From our library of Articles, Sigma-Aldrich presents US EPA Method 8100: GC Analysis of Polynuclear Aromatic Hydrocarbons (PAHs) on SPB®-608
Keywords: Chromatography, Gas chromatography, Purification

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on Equity®-5 (30 m x 0.25 mm I.D., 0.50 μm)
Keywords: Chromatography, Gas chromatography, Mass selective detector, Purification

US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on SLB®-5ms (30 m x 0.25 mm I.D., 0.50 μm)

From our library of Articles, Sigma-Aldrich presents US EPA Method 8270 (Appendix IX): GC Analysis of Semivolatiles on SLB®-5ms (30 m x 0.25 mm I.D., 0.50 μm)
Keywords: Chromatography, Gas chromatography, Purification

Peer-Reviewed Papers
15

References

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