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  • 224M-1 - Beta-Catenin (14) Mouse Monoclonal Antibody

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224M-1 Sigma-Aldrich

Beta-Catenin (14) Mouse Monoclonal Antibody

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Anatomic Pathology, Antibodies, CAM-CB, Cell Marque Antibodies,
conjugate   unconjugated
clone   14, monoclonal
biological source   mouse
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
packaging   vial of 0.1 mL concentrate (224M-14)
  vial of 0.5 mL concentrate (224M-15)
  bottle of 1.0 mL predilute (224M-17)
  vial of 1.0 mL concentrate (224M-16)
  bottle of 7.0 mL predilute (224M-18)
antibody form   culture supernatant
isotype   IgG1
antibody product type   primary antibodies
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
mfr. no.   Cell Marque
concentration   1.0-5.0 μg/mL (predilute)
  25-125 μg/mL (concentrate)
control   fibromatosis of breast
visualization   membranous, nuclear

Description

General description

Beta-Catenin is a 92 kD protein normally found in the cytoplasm of the cell in the submembranous location. This protein is associated with E-Cadherin and may be essential for the function of E-Cadherin. Mutations in the Beta-Catenin gene result in nuclear accumulation of this protein. Nuclear accumulation of this protein has been demonstrated in fibromatosis lesions of the breast and abdomen and therefore is useful in differentiating this lesion from other spindle cell lesions that may occur in these locations. Nuclear accumulation of Beta-Catenin has also been demonstrated in colorectal carcinoma.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Quality


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RUO

Linkage

Beta-Catenin Positive Control Slides, Product No. 224S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Immunohistochemistry: Current Applications in Gastrointestinal Cancer

Incidence Deaths Lifetime risk of Colorectal Cancer Signs and Symptoms Immunohistochemistry and Colon Cancer Metastatic Carcinoma [Webinar] Colorectal Cancer and Immunohistochemistry Materials Refere...
Mike Lacey
M.D. Pathologist and Chief Medical Officer
Keywords: Adhesion, Cancer, Clinical, Diagnostic, Gastrointestinal, Gene expression, Genetics, Growth factors, Hormones, Immunohistochemistry, Immunostaining, Indicators, Microscopy, Morphogenesis, Obesity, Transcription

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Peer-Reviewed Papers
15

References

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224S Beta-Catenin Positive Control Slides, suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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