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229075 Sigma-Aldrich

1,8-Dihydroxy-3-methylanthraquinone

98%

Synonym: 3-Methylchrysazin, Chrysophanic acid

  • CAS Number 481-74-3

  • Empirical Formula (Hill Notation) C15H10O4

  • Molecular Weight 254.24

  •  Beilstein/REAXYS Number 1252300

  •  EC Number 207-572-2

  •  MDL number MFCD00001208

  •  PubChem Substance ID 57648009

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Properties

Related Categories Aloe Vera, Building Blocks, C15 to C38, Carbonyl Compounds, Cell Biology,
InChI Key   LQGUBLBATBMXHT-UHFFFAOYSA-N
assay   98%
form   crystalline
color   yellow-orange
solubility   chloroform: 1%
Mode of action   enzyme | inhibits
antibiotic activity spectrum   neoplastics
  viruses
Gene Information   human ... ELA2(1991)

Description

Application

Chrysophanic acid, a natural anthraquinone, is used to study anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells . It is also used to study the inhibition of replication of poliovirus types 2 and 3 (Picornaviridae) in vitro .

Packaging

1 g in glass bottle

50 mg in glass insert

Biochem/physiol Actions

Anticancer activity for chrysophanic acid is via the EGFR/mTOR mediated signaling transduction pathway . Chrysophanic acid has two hydrophobic positions on the molecule (C-6 and the methyl group attached to C-3) which are responsible for the compound′s activity against poliovirus .

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
CB6725000

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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