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  • 241R-4 - Cyclin D1 (EP12) Rabbit Monoclonal Primary Antibody

241R-4 Sigma-Aldrich

Cyclin D1 (EP12) Rabbit Monoclonal Primary Antibody

  •  NACRES NA.41



Related Categories Alphabetical Index, Antibodies, CT-CZ, Cell Marque Antibodies, Hematopathology,
conjugate   unconjugated
clone   EP12, monoclonal
biological source   rabbit
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
packaging   vial of 0.1 mL concentrate (241R-44)
  vial of 0.5 mL concentrate (241R-45)
  bottle of 1.0 mL predilute (241R-47)
  vial of 1 mL concentrate (241R-46)
  bottle of 7.0 mL predilute (241R-48)
antibody form   culture supernatant
isotype   IgG
Quality Level   100
antibody product type   primary antibodies
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
mfr. no.   Cell Marque
concentration   0.5-1.5 μg/mL (predilute)
  25-75 μg/mL (concentrate)
dilution   1:100-1:500
control   mantle cell lymphoma
visualization   nuclear


General description

Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. Cyclins are proteins that govern transitions through distinct phases of the cell cycle by regulating the activity of the cyclin-dependent kinases. In mid-to-late G1 phase of the cell cycle, cyclin D1 shows a maximum expression following growth factor stimulation. Anti-cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities. This antibody is useful for separating mantle cell lymphomas (cyclin D1 positive) from chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphomas (cyclin D1 negative). Hairy cell leukemia and plasma cell myeloma can weakly express Cyclin D1.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC







Cyclin D1 Positive Control Slides, Product No. 241S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Safety & Documentation

Safety Information

NONH for all modes of transport


Certificate of Analysis (COA)

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Protocols & Articles


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241S Cyclin D1 Positive Control Slides, suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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