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  • 241R-4 - Cyclin D1 (EP12) Rabbit Monoclonal Primary Antibody

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241R-4 Sigma-Aldrich

Cyclin D1 (EP12) Rabbit Monoclonal Primary Antibody

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Properties

Related Categories Alphabetical Index, Antibodies, CT-CZ, Cell Marque Antibodies, Hematopathology,
Quality Level   GMP-IVD
biological source   rabbit
antibody form   culture supernatant
antibody product type   primary antibodies
clone   EP12, monoclonal
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (241R-44)
  vial of 0.5 mL concentrate (241R-45)
  bottle of 1.0 mL predilute (241R-47)
  vial of 1 mL concentrate (241R-46)
  bottle of 7.0 mL predilute (241R-48)
mfr. no.   Cell Marque
concentration   0.5-1.5 μg/mL (predilute)
  25-75 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
dilution   1:100-1:500
isotype   IgG
conjugate   unconjugated
control   mantle cell lymphoma
shipped in   wet ice
storage temp.   2-8°C
visualization   nuclear

Description

General description

Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. Cyclins are proteins that govern transitions through distinct phases of the cell cycle by regulating the activity of the cyclin-dependent kinases. In mid-to-late G1 phase of the cell cycle, cyclin D1 shows a maximum expression following growth factor stimulation. Anti-cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities. This antibody is useful for separating mantle cell lymphomas (cyclin D1 positive) from chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphomas (cyclin D1 negative). Hairy cell leukemia and plasma cell myeloma can weakly express Cyclin D1.

Linkage

Cyclin D1 Positive Control Slides, Product No. 241S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Preparation Note

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Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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241S Cyclin D1 Positive Control Slides, immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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