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26430 Sigma

Chlortetracycline hydrochloride

suitable for fluorescence, BioReagent, from Streptomyces aureofaciens, ≥97.0% (AT)

Synonym: 7-Chlorotetracycline hydrochloride

  • CAS Number 64-72-2

  • Empirical Formula (Hill Notation) C22H23ClN2O8 · HCl

  • Molecular Weight 515.34

  •  Beilstein Registry Number 3858364

  •  EC Number 200-591-7

  •  MDL number MFCD00082440

  •  PubChem Substance ID 57648175

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics A-F,
biological source   Streptomyces aureofaciens
InChI Key   CBHYYLPALVVVEY-LYNLVHCPSA-N
product line   BioReagent
assay   ≥97.0% (AT)
form   solid
impurities   ≤3% water
color   faintly yellow to yellow
mp   210-215 °C (dec.) (lit.)
solubility   H2O: 50 mg/mL
fluorescence   λex 392 nm; λem 536 nm in 0.1 M Tris pH 8.0, 10 mM Ca2+
suitability   suitable for fluorescence
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   −20°C

Description

Application

Cell-permeable fluorescent probe for Ca2+ for measuring calcium flux in endoplasmic reticulum and other intracellular stores in situ.

Biochem/physiol Actions

Chlortetracycline is an antibiotic produced by some strains of Streptomyces aureofaciens.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-positive. Less active against Gram-negative bacteria than tetracycline.
Mode of Resistance: Loss of cell wall permeability.

Packaging

5 g, 25 g, 100g

Quality

Recommended for fluorescent studies of calcium signaling in cells or tissues.

General description

Chemical structure: tetracycline

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
QI7800000
Protocols & Articles
Peer-Reviewed Papers
15

References

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