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26978 Sigma-Aldrich

Choline chloride

BioUltra, ≥99.0% (AT)

Synonym: (2-Hydroxyethyl)trimethylammonium chloride

  • CAS Number 67-48-1

  • Linear Formula (CH3)3N(Cl)CH2CH2OH

  • Molecular Weight 139.62

  •  Beilstein/REAXYS Number 3563126

  •  EC Number 200-655-4

  •  MDL number MFCD00011721

  •  PubChem Substance ID 57648187

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Properties

Related Categories Cell Biology, Glycerolipid Metabolism, Metabolic Pathways, Metabolomics, Nutrition Research,
biological source   synthetic
InChI Key   SGMZJAMFUVOLNK-UHFFFAOYSA-M
product line   BioUltra
assay   ≥99.0% (AT)
form   powder or crystals
impurities   insoluble matter, passes filter test
color   colorless to white
pH   5.0-7.5 (25 °C, 1 M in H2O)
mp   302-305 °C (dec.) (lit.)
solubility   H2O: 1 M, clear, colorless
anion traces   sulfate (SO42-): ≤50 mg/kg
cation traces   Al: ≤5 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
λ   1 M in H2O
UV absorption   λ: 260 nm Amax: 0.015
  λ: 280 nm Amax: 0.010

Description

Biochem/physiol Actions

The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Choline is an essential nutrient, commonly grouped with the B complex vitamins, that plays key roles in many biological processes.

Substrates

Choline acetyltransferase substrate

Other Notes

Restores cholinergic, biochemical and pharmacological activities in striata of decorticated rats

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Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
KH2975000

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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