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274M-9 Sigma-Aldrich

Kappa (L1C1) Mouse Monoclonal Antibody

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Properties

Related Categories Alphabetical Index, Antibodies, Cell Marque Antibodies, Hematopathology, K-KH,
conjugate   unconjugated
clone   L1C1, monoclonal
biological source   mouse
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
packaging   vial of 0.1 mL concentrate (274M-94)
  vial of 0.5 mL concentrate (274M-95)
  bottle of 1.0 mL predilute (274M-97)
  vial of 1.0 mL concentrate (274M-96)
  bottle of 7.0 mL predilute (274M-98)
antibody form   culture supernatant
isotype   IgG1κ
antibody product type   primary antibodies
Quality Level   GMP-IVD
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
mfr. no.   Cell Marque
concentration   0.01-1.0 μg/mL (predilute)
  0.5-50 μg/mL (concentrate)
control   tonsil
visualization   cytoplasmic

Description

General description

Anti-Kappa detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, anti-kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulins. When dealing with B-cell neoplasms, the determination of light chain ratios remains the centerpiece. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder exists. Monoclonality is determined by a kappa-lambda ratio of greater than or equal to 3:1 or a lambda-kappa ratio greater than 2:1.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Quality


IVD

IVD

IVD

RUO

Linkage

Kappa Positive Control Slides, Product No. 274S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Preparation Note

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Note: This requires a keycode which can be found on your packaging or product label.

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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Description

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274S Kappa Positive Control Slides, suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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