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27689 Sigma-Aldrich

Concanamycin A

from Streptomyces sp., ≥80% (HPLC)

Synonym: Folimycin

  • CAS Number 80890-47-7

  • Empirical Formula (Hill Notation) C46H75NO14

  • Molecular Weight 866.09

  •  Beilstein/REAXYS Number 3560277

  •  MDL number MFCD00210037

  •  PubChem Substance ID 329753012

  •  NACRES NA.25

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics by Application, Antibiotics by Mechanism of Action, Antibiotics  A-F,
Quality Level   100
biological source   Streptomyces sp.
assay   ≥80% (HPLC)
Mode of action   enzyme | inhibits
antibiotic activity spectrum   viruses
storage temp.   −20°C
SMILES string   CCC1C(O)C(C)C\C(C)=C\C=C\C(OC)C(OC(=O)\C(OC)=C\C(C)=C\C(C)C1O)C(C)C(O)C(C)[C@]2(O)C[C@@H](O[C@H]3C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O3)[C@H](C)C(O2)\C=C\C
InChI   1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26?,27?,28-,29?,30?,31-,32?,33-,34?,35?,37-,38+,39?,40?,41?,42?,43-,46+/m1/s1
InChI key   DJZCTUVALDDONK-LWLXYWDNSA-N

Description

General description

Chemical structure: macrolide

Application

Concanamycin A has been used as an inhibitor of the perforin pathway.

Other Notes

Characterization of concanamycins A, B and C; Selective inhibitor of the vacuolar proton-ATPase.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3462 6.1 / PGII
WGK Germany 
WGK 3
RTECS 
CB9732000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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