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27691 Sigma-Aldrich

Concanamycin C from Streptomyces sp.

~95% (HPLC)

  • CAS Number 81552-34-3

  • Empirical Formula (Hill Notation) C45H74O13

  • Molecular Weight 823.06

  •  Beilstein/REAXYS Number 6628190

  •  MDL number MFCD00216692

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Properties

assay   ~95% (HPLC)
Mode of action   enzyme | inhibits
antibiotic activity spectrum   viruses
storage temp.   −20°C
SMILES string   CC[C@H]1[C@@H](O)[C@H](C)C\C(C)=C\C=C\[C@H](OC)C(OC(=O)\C(OC)=C\C(C)=C\[C@@H](C)[C@H]1O)[C@@H](C)[C@@H](O)[C@H](C)[C@@]2(O)C[C@@H](O[C@H]3C[C@@H](O)[C@H](O)[C@@H](C)O3)[C@H](C)[C@H](O2)\C=C\C

Description

General description

Chemical structure: macrolide

Application

Cancanamycin C, a vacuolar AT Pase, is used to suppress antigen presentation by MHC class II molecules. V-ATPases are responsible for the acidification of eukaryotic organelles such as endosomes and lysosomes and the vacuoles of plants and fungi

Biochem/physiol Actions

Concanamycin C inhibits v-ATPase (vacuolar-ATPase) and perturbs vacuolar organelle, endosome, and lysosome acidification processes. Used to suppress antigen presentation by MHC class II molecules.

Concanamycin C inhibits v-ATPase (vacuolar-ATPase) and perturbs vacuolar organelle, endosome, and lysosome acidification processes. Vacuolar ATPases, such as Concanamycin C, pump protons into the lumen of various endomembrane systems and cellular compartments .

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGI
WGK Germany 
3
RTECS 
GK6887000

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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