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315R-1 Sigma-Aldrich

PD-1 (EP239) Rabbit Monoclonal Primary Antibody

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Synonym: CD279, PD1, PDCD1, SLEB2, hPH-1, hSLE1, programmed cell death 1, programmed cell death protein 1, protein PD-1, systemic lupus erythematosus suseptibilitl 2

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Properties

Quality Level   100
  500
biological source   rabbit
antibody form   culture supernatant
antibody product type   primary antibodies
clone   EP239, monoclonal
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (315R-14)
  vial of 0.1 mL concentrate Research Use Only (315R-14-RUO)
  vial of 0.5 mL concentrate (315R-15)
  vial of 1.0 mL concentrate (315R-16)
  vial of 1.0 mL concentrate Research Use Only (315R-16-RUO)
  vial of 1.0 mL pre-dilute Research Use Only (315R-17-RUO)
  vial of 1.0 mL predilute ready-to-use (315R-17)
  vial of 7.0 mL pre-dilute ready-to-use Research Use Only (315R-18-RUO)
  vial of 7.0 mL predilute ready-to-use (315R-18)
mfr. no.   Cell Marque
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
isotype   IgG
conjugate   unconjugated
control   lymph node, tonsil
shipped in   wet ice
storage temp.   2-8°C
visualization   cytoplasmic, membranous

Description

General description

Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PD-1 is expressed by few B-cells, so anti-PD-1 may be a more specific and useful marker in the identification of angioimmunoblastic lymphoma. In addition, PD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. PD-1 expression in angioimmunoblastic lymphoma lends further support to this model of T-cell oncogenesis, in which specific subtypes of T-cells may undergo neoplastic transformation and result in specific distinct histologic, immunophenotypic, and clinical subtypes of T-cell neoplasia.,,,,,

Quality

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Linkage

PD-1 Positive Control Slides, Product No. 315S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Predilute: diluted in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Concentrate: diluted in Phosphate Buffered Saline, pH 7.2, with 1% BSA and <0.1% Sodium Azide

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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