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31995 Sigma-Aldrich

Barbital

BioXtra, ≥99.0% (T)

Synonym: 5,5-Diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione, 5,5-Diethylbarbituric acid, Barbitone, Veronal

  • CAS Number 57-44-3

  • Empirical Formula (Hill Notation) C8H12N2O3

  • Molecular Weight 184.19

  •  Beilstein/REAXYS Number 163999

  •  EC Number 200-331-2

  •  MDL number MFCD00036212

  •  PubChem Substance ID 57648640

  •  NACRES NA.21

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Properties

Related Categories Additional Standards, Analytical Standards, Analytical/Chromatography, Barbiturates, Chemical Structure,
Quality Level   200
product line   BioXtra
assay   ≥99.0% (T)
drug control   USDEA Schedule IV; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
ign. residue   ≤0.1% (as SO4)
loss   ≤0.5% loss on drying, 20 °C (HV)
mp   189-191 °C
solubility   alcohol: soluble 1 gm in 14 ml
  chloroform: soluble 1 gm in 75 ml
  diethyl ether: soluble 1 gm in 35 ml
  water: soluble 1 gm in 13 ml (boiling)
  water: soluble 1 gm in 130 ml
  acetone: soluble
  ethyl acetate: soluble
  nitrobenzene: soluble
  petroleum ether: soluble
  pyridine: soluble
anion traces   chloride (Cl-): ≤500 mg/kg
  sulfate (SO42-): ≤50 mg/kg
cation traces   Ca: ≤50 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Na: ≤200 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Zn: ≤5 mg/kg
Featured Industry   Forensics and Toxicology
Pharmaceutical (small molecule)
Veterinary
SMILES string   CCC1(CC)C(=O)NC(=O)NC1=O
InChI   1S/C8H12N2O3/c1-3-8(4-2)5(11)9-7(13)10-6(8)12/h3-4H2,1-2H3,(H2,9,10,11,12,13)
InChI key   FTOAOBMCPZCFFF-UHFFFAOYSA-N

Description

Application

Barbital has been used as an assay buffer for determining the carbonic anhydrase activity. It has also been used for rocket immunoelectrophoresis.

Biochem/physiol Actions

Barbital also referred to as 5,5-Diethylbarbituric acid, Barbitone or Veronal is a sedative/hypnotic (sleeping aid). It stimulates the development of tumors in rats treated with a sub-effective dose of N-bis(2-hydroxypropyl)nitrosamine (DHPN).

Sedative/hypnotic

Other Notes

Sales restrictions may apply

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
CQ3500000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Barbiturates on Ascentis® C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Barbiturates on Ascentis® C18
Keywords: Anticonvulsants, Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical, Separation, Solvents

HPLC Analysis of Barbiturates on Ascentis® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Barbiturates on Ascentis® C8
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Barbiturates on Discovery® C18, Unbuffered Mobile Phase

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Barbiturates on Discovery® C18, Unbuffered Mobile Phase
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Barbiturates on Discovery® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Barbiturates on Discovery® C8
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Barbiturates on Discovery® RP-AmideC16

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Barbiturates on Discovery® RP-AmideC16
Keywords: Anticonvulsants, Chromatography, High performance liquid chromatography, Pharmaceutical

TLC Analysis of Drugs on HPTLC Silica Gel 60 RP-18 F254s

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Drugs on HPTLC Silica Gel 60 RP-18 F254s
Keywords: Chromatography, Pharmaceutical, Thin layer chromatography

UHPLC Analysis of Barbiturates on Titan™ C18

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Barbiturates on Titan™ C18
Keywords: Anti-depressants, Anticonvulsants, Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Pharmaceutical, Solvents

Peer-Reviewed Papers
15

References

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