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324M-1 Sigma-Aldrich

PSA (ER-PR8) Mouse Monoclonal Antibody

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Properties

Related Categories Alphabetical Index, Anatomic Pathology, Antibodies, Cell Marque Antibodies, Genitourinary (GU) Pathology,
conjugate   unconjugated
clone   ER-PR8, monoclonal
biological source   mouse
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
packaging   vial of 0.1 mL concentrate (324M-14)
  vial of 0.5 mL concentrate (324M-15)
  bottle of 1.0 mL predilute (324M-17)
  vial of 1.0 mL concentrate (324M-16)
  bottle of 7.0 mL predilute (324M-18)
antibody form   culture supernatant
isotype   IgG1κ
antibody product type   primary antibodies
Quality Level   GMP-IVD
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
mfr. no.   Cell Marque
concentration   0.01-1 μg/mL (predilute)
  0.25-25 μg/mL (concentrate)
control   prostate
visualization   cytoplasmic

Description

General description

Prostate-Specific Antigen (PSA) is a 33 kDa protein primarily produced by the prostatic epithelium and the epithelial lining of the periurethral glands . PSA is strongly expressed in both normal and neoplastic prostatic tissue. Although PSA can be considered prostate-specific, PSA and/or PSA gene expression has been detected at low levels in some extra-prostatic tissues such as normal breast tissue, breast tumors, endometrium, adrenal neoplasms and renal cell carcinomas. Anti-PSA is most useful in determining the prostatic origin of carcinomas in non-prostate tissues (metastatic disease) using IHC techniques. This product is best used in conjunction with a panel of antibodies as, up to 27% of prostate carcinoma cases (predominantly poorly differentiated carcinomas) can be negative for this marker.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

PSA Positive Control Slides, Product No. 324S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Preparation Note

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Quality


IVD

IVD

RUO

RUO

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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Description

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324S PSA Positive Control Slides, immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

Technical Service:

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