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330M-1 Sigma-Aldrich

S-100 (4C4.9) Mouse Monoclonal Antibody

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Properties

Related Categories Alphabetical Index, Antibodies, Cell Marque Antibodies, Dermatopathology, Primary Antibodies,
Quality Level   GMP-IVD
biological source   mouse
antibody form   diluted ascites fluid
antibody product type   primary antibodies
clone   4C4.9, monoclonal
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (330M-14)
  vial of 0.5 mL concentrate (330M-15)
  bottle of 1.0 mL predilute (330M-17)
  vial of 1.0 mL concentrate (330M-16)
  bottle of 7.0 mL predilute (330M-18)
mfr. no.   Cell Marque
concentration   0.15-0.28 μg/mL (predilute)
  15-28 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
isotype   IgG2a
conjugate   unconjugated
control   melanoma
shipped in   wet ice
storage temp.   2-8°C
visualization   cytoplasmic, nuclear

Description

General description

S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells.Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein. Despite the fact that S-100 protein is an ubiquitous substance, its demonstration is of great value in the identification of several neoplasms, particularly melanomas.

Linkage

S-100 Positive Control Slides, Product No. 330S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Preparation Note

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Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Immunohistochemistry: Current Applications in Skin Cancer

Cutaneous Spindle Cell Tumors Cutaneous Adnexal Neoplasms Melanocytic Neoplasms Malignant Small Blue Cell Tumors Fibrohistiocytic Lesions Vascular Neoplasms Hematopoietic and Hystiocytic Tumors Infec...
Mike Lacey
M.D. Pathologist and Chief Medical Officer
Keywords: AGE, Addition reactions, Adhesion, Cancer, Cell biology, Clinical, Condensations, Diagnostic, Diseases, Gastrointestinal, Gene expression, Genetic, Growth factors, Immunohistochemistry, Immunostaining, Indicators, Infectious Diseases, Inflammation, Microarray Analysis, Microscopy, Polymerase chain reaction, Techniques and applications, Tissue microarrays, Transcription

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Peer-Reviewed Papers
15

References

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330S S-100 Positive Control Slides, immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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