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334M-8 Sigma-Aldrich

Cytokeratin (34betaE12) Mouse Monoclonal Antibody

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Properties

Related Categories Alphabetical Index, Anatomic Pathology, Antibodies, CT-CZ, Cell Marque Antibodies,
Quality Level   GMP-IVD
biological source   mouse
antibody form   culture supernatant
antibody product type   primary antibodies
clone   34betaE12, monoclonal
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (334M-84)
  vial of 0.5 mL concentrate (334M-85)
  bottle of 1.0 mL predilute (334M-87)
  vial of 1.0 mL concentrate (334M-86)
  bottle of 7.0 mL predilute (334M-88)
mfr. no.   Cell Marque
concentration   1-10 μg/mL (predilute)
  100-1000 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype   IgG1κ
conjugate   unconjugated
control   prostate
shipped in   wet ice
storage temp.   2-8°C
visualization   cytoplasmic

Description

General description

Anti-Cytokeratin, 34betaE12 is an antibody to high molecular weight cytokeratin that reacts with all squamous and ductal epithelium and stains carcinomas. This antibody recognizes cytokeratins 1,5,10, and 14 that are found in complex epithelia. Anti-Cytokeratin, 34betaE12 shows no reactivity with hepatocytes, pancreatic acinar cells, proximal renal tubules, or endometrial glands; there has been no reactivity with cells derived from simple epithelia. Mesenchymal tumors, lymphomas, melanomas, and neural tumors are unreactive with this antibody with some exceptions. Anti-Cytokeratin, 34betaE12 does label myoepithelial cells and has been shown to be useful in distinguishing prostatic adenocarcinoma from hyperplasia of the prostate. This antibody has also been useful in separating benign from malignant intraductal breast proliferations.

Linkage

Cytokeratin (34betaE12) Positive Control Slides , Product No. 334S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Preparation Note

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Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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334S Cytokeratin 34betaE12 Positive Control Slides, immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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