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336A-7 Sigma-Aldrich

Synaptophysin Rabbit Polyclonal Antibody

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Properties

Related Categories Alphabetical Index, Anatomic Pathology, Antibodies, Cell Marque Antibodies, Primary Antibodies,
Quality Level   GMP-IVD
biological source   rabbit
antibody form   Ig fraction of antiserum
antibody product type   primary antibodies
clone   polyclonal
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (336A-74)
  vial of 0.5 mL concentrate (336A-75)
  bottle of 1.0 mL predilute (336A-77)
  vial of 1.0 mL concentrate (336A-76)
  bottle of 7.0 mL predilute (336A-78)
mfr. no.   Cell Marque
concentration   1-5 μg/mL (predilute)
  100-500 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
conjugate   unconjugated
control   pancreas
shipped in   wet ice
storage temp.   2-8°C
visualization   cytoplasmic

Description

General description

Anti-synaptophysin reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary, thyroid, lung, pancreas, and gastrointestinal mucosa. Positive staining is seen in neurons of the brain, spinal cord, retina, Paneth cells in the gastrointestinal tract, and gastric parietal cells. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. The expression of synaptophysin is independent of the presence of NSE or other neuroendocrine markers. Anti-synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.

Linkage

Synaptophysin Positive Control Slides , Product No. 336S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
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Immunohistochemistry: Current Applications in Gastrointestinal Cancer

Incidence Deaths Lifetime risk of Colorectal Cancer Signs and Symptoms Immunohistochemistry and Colon Cancer Metastatic Carcinoma [Webinar] Colorectal Cancer and Immunohistochemistry Materials Refere...
Mike Lacey
M.D. Pathologist and Chief Medical Officer
Keywords: Adhesion, Cancer, Clinical, Diagnostic, Gastrointestinal, Gene expression, Genetics, Growth factors, Hormones, Immunohistochemistry, Immunostaining, Indicators, Microscopy, Morphogenesis, Obesity, Transcription

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Peer-Reviewed Papers
15

References

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336S Synaptophysin Positive Control Slides, immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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