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343M-9 Sigma-Aldrich

TTF-1 (8G7G3/1) Mouse Monoclonal Antibody

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Properties

Related Categories Alphabetical Index, Anatomic Pathology, Antibodies, Cell Marque Antibodies, Primary Antibodies,
Quality Level   GMP-IVD
biological source   mouse
antibody form   culture supernatant
antibody product type   primary antibodies
clone   8G7G3/1, monoclonal
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (343M-94)
  vial of 0.5 mL concentrate (343M-95)
  bottle of 1.0 mL predilute (343M-97)
  vial of 1.0 mL concentrate (343M-96)
  bottle of 7.0 mL predilute (343M-98)
mfr. no.   Cell Marque
concentration   2.5-10 μg/mL (predilute)
  250-1000 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype   IgG1
conjugate   unconjugated
control   lung adenocarcinoma
shipped in   wet ice
storage temp.   2-8°C
visualization   nuclear

Description

General description

Anti-TTF-1 (Thyroid Transcription Factor 1) is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the organs rather than thyroid, germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. TTF-1 labeling is also seen in thyroid and thyroid-derived tumors TTF-1 immunostaining is useful in the differentiation between pulmonary and nonpulmonary origin of adenocarcinomas in malignant effusions. TTF-1 staining is very reliable in discerning whether a brain metastasis has arisen from a pulmonary or nonpulmonary site, particularly when dealing with adenocarcinomas and large-cell carcinomas.

Linkage

TTF-1 Positive Control Slides, Product No. 343S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Preparation Note

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Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

Immunohistochemistry: Current Applications in Gastrointestinal Cancer

Incidence Deaths Lifetime risk of Colorectal Cancer Signs and Symptoms Immunohistochemistry and Colon Cancer Metastatic Carcinoma [Webinar] Colorectal Cancer and Immunohistochemistry Materials Refere...
Mike Lacey
M.D. Pathologist and Chief Medical Officer
Keywords: Adhesion, Cancer, Clinical, Diagnostic, Gastrointestinal, Gene expression, Genetics, Growth factors, Hormones, Immunohistochemistry, Immunostaining, Indicators, Microscopy, Morphogenesis, Obesity, Transcription

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Peer-Reviewed Papers
15

References

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343S TTF-1 Positive Control Slides, immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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