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358M-1 Sigma-Aldrich

MUM1 (MRQ-8) Mouse Monoclonal Antibody

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Properties

Related Categories Alphabetical Index, Antibodies, Cell Marque Antibodies, Hematopathology, MS-MUD,
Quality Level   GMP-IVD
biological source   mouse
antibody form   culture supernatant
antibody product type   primary antibodies
clone   MRQ-8, monoclonal
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (358M-14)
  vial of 0.5 mL concentrate (358M-15)
  bottle of 1.0 mL predilute (358M-17)
  vial of 1.0 mL concentrate (358M-16)
  bottle of 7.0 mL predilute (358M-18)
mfr. no.   Cell Marque
concentration   0.01-1 μg/mL (predilute)
  25-75 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype   IgG1κ
conjugate   unconjugated
control   B-cell chronic lymphocytic leukemia (B-CLL), plasma cell myeloma, tonsil
shipped in   wet ice
storage temp.   2-8°C
visualization   cytoplasmic, nuclear

Description

General description

MUM1 (multiple myeloma oncogene-1)/IRF4 (interferon regulatory factor 4) is a 50 kDa protein encoded by MUM1 gene, and a member of the interferon regulatory factor family of transcription factors. MUM1/IRF4 is expressed in the nuclei of plasma cells and a small percentage of germinal center (GC) B-cells located in the “light zone”. This antibody stains MUM1 protein, which is expressed in a subset of B-cells in the light zone of the germinal center, plasma cells, activated T-cells, and a wide spectrum of related hematolymphoid neoplasms derived from these cells. Therefore, this antibody is useful for the subclassiffication of lymphoid malignancies and an excellent marker for Reed-Sternberg cells of classic Hodgkin disease in combination with anti-CD30.

Linkage

MUM1 Positive Control Slides, Product No. 358S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Preparation Note

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Quality


IVD

IVD

IVD

RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis

Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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358S MUM1 Positive Control Slides, immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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