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  • 385M-1 - SALL4 (6E3) Mouse Monoclonal Antibody

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385M-1 Sigma-Aldrich

SALL4 (6E3) Mouse Monoclonal Antibody

  •  NACRES NA.41

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Properties

Related Categories Alphabetical Index, Antibodies, Cell Marque Antibodies, Genitourinary (GU) Pathology, Primary Antibodies,
conjugate   unconjugated
clone   6E3, monoclonal
biological source   mouse
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
packaging   vial of 0.1 mL concentrate (385M-14)
  vial of 0.5 mL concentrate (385M-15)
  bottle of 1.0 mL predilute (385M-17)
  vial of 1.0 mL concentrate (385M-16)
  bottle of 7.0 mL predilute (385M-18)
antibody form   culture supernatant
isotype   IgG1
Quality Level   100
  500
antibody product type   primary antibodies
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
mfr. no.   Cell Marque
concentration   0.01-2.0 μg/mL (predilute)
  1-50 μg/mL (concentrate)
control   dysgerminoma, seminoma
visualization   nuclear

Description

General description

SALL4 is a zinc finger transcription factor. Anti-SALL4 demonstrates 100% sensitivity and stains more than 90% tumor cells in all intratubular germ cell neoplasia, seminomas/dysgerminomas, embryonal carcinomas, and yolk sac tumor (YST) (both pediatric and postpubertal). Anti-SALL4 also stains most cases of teratoma and the mononucleated trophoblastic cells in choriocarcinomas. In contrast, non-germ cell tumors show no anti-SALL4 staining. Most non-testicular tumors from various organs and sites are negative for anti-SALL4, though an occasional carcinoma or sarcoma may show weak anti-SALL4 staining in less than 25% of tumor cells. In normal testicular tissue, positive, weak anti-SALL4 staining is observed in spermatogonia. In addition, a few (<5%) primary spermatocytes showed dot-like weak anti-SALL4 staining. Secondary spermatocytes, spermatids, spermatozoa, and Sertoli cells are negative for anti-SALL4. Leydig cells, rete testis, epididymis, spermatic cord fibroblasts, blood vessels, and hematopoietic cells are negative for anti-SALL4.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Quality


IVD

IVD

IVD

RUO

Linkage

SALL4 Positive Control Slides, Product No. 385S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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385S SALL4 Positive Control Slides, suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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