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39220 Sigma-Aldrich

Dansyl chloride

BioReagent, suitable for fluorescence, ≥99.0% (HPLC)

Synonym: 5-(Dimethylamino)naphthalene-1-sulfonyl chloride, DNSCl

  • CAS Number 605-65-2

  • Empirical Formula (Hill Notation) C12H12ClNO2S

  • Molecular Weight 269.75

  •  Beilstein/REAXYS Number 2217205

  •  EC Number 210-092-6

  •  MDL number MFCD00003985

  •  PubChem Substance ID 329755828

  •  NACRES NA.32

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Properties

Related Categories Alphabetical, Amino Acid Analysis, Amino Acids, Analytical Reagents, Analytical/Chromatography,
Quality Level   200
product line   BioReagent
assay   ≥99.0% (HPLC)
mp   72-74 °C (lit.)
solubility   acetone: 0.2 g/10 mL
fluorescence   λex 337 nm; λem 492 nm in chloroform (after derivatization with hexylamine)
suitability   suitable for fluorescence
storage temp.   2-8°C
SMILES string   CN(C)c1cccc2c(cccc12)S(Cl)(=O)=O
InChI   1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3
InChI key   XPDXVDYUQZHFPV-UHFFFAOYSA-N

Description

Application

Dansyl chloride (DNSC), a primary amine reactive agent, is widely used as a fluorogenic reagent for N-terminal derivatization of amino acids and peptides and for polyamine detection by reverse phase HPLC and other analytical procedures.

A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.

Safety & Documentation

Safety Information

Symbol 
GHS05  GHS05
Signal word 
Danger
Hazard statements 
RIDADR 
UN 3261 8 / PGII
WGK Germany 
WGK 3
RTECS 
QK3688000

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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