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  • 404R-1 - C4d (SP91) Rabbit Monoclonal Antibody

404R-1 Sigma-Aldrich

C4d (SP91) Rabbit Monoclonal Antibody



Related Categories Alphabetical Index, Antibodies, C2-C9, Cell Marque Antibodies, Primary Antibodies,
conjugate   unconjugated
clone   SP91, monoclonal
biological source   rabbit
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
packaging   vial of 0.1 mL concentrate (404R-14)
  vial of 0.5 mL concentrate (404R-15)
  bottle of 1.0 mL predilute (404R-17)
  vial of 1.0 mL concentrate (404R-16)
  bottle of 7.0 mL predilute (404R-18)
antibody form   culture supernatant
isotype   IgG
antibody product type   primary antibodies
Quality Level   GMP-IVD
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
mfr. no.   Cell Marque
concentration   2.5-10.0 μg/mL (predilute)
  60-250 μg/mL (concentrate)
control   lymph node, tonsil
visualization   cytoplasmic, membranous


General description

C4d is a stable split product remnant of classical complement activation which becomes covalently bound to endothelium and basement membrane after induction of the classical antibody-induced pathway. As an established marker of antibody-mediated acute renal allograft rejection (AR) and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be closely correlated with transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of AR that may serve to warrant prompt and aggressive anti-rejection treatment.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC







C4d Positive Control Slides, Product No. 404S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Safety & Documentation

Safety Information

NONH for all modes of transport


Certificate of Analysis

Protocols & Articles


Antibody Basics

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404S C4d Positive Control Slides, suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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