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  • 412M-1 - Caveolin-1 (2297) Mouse Monoclonal Antibody

412M-1 Sigma-Aldrich

Caveolin-1 (2297) Mouse Monoclonal Antibody

  •  NACRES NA.41



Related Categories Alphabetical Index, Antibodies, CAM-CB, Cell Marque Antibodies, Cytopatholgy,
conjugate   unconjugated
clone   2297, monoclonal
biological source   mouse
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
species reactivity   human
form   buffered aqueous solution
shipped in   wet ice
storage temp.   2-8°C
packaging   vial of 0.1 mL concentrate (412M-14)
  vial of 0.5 mL concentrate (412M-15)
  bottle of 1.0 mL predilute (412M-17)
  vial of 1.0 mL concentrate (412M-16)
  bottle of 7.0 mL predilute (412M-18)
antibody form   culture supernatant
isotype   IgG1
Quality Level   100
antibody product type   primary antibodies
description   For In Vitro Diagnostic Use in Select Regions (See Chart)
mfr. no.   Cell Marque
concentration   0.01-1 μg/mL (predilute)
  0.25-25 μg/mL (concentrate)
control   Ewing’s sarcoma, mesothelioma
visualization   membranous


General description

Caveolin-1 (CAV-1) is a cell membrane-associated structural component of flask-shaped plasma membrane invaginations termed caveolae. CAV-1 is expressed at different levels in different tissues, with the highest in adipocytes, endothelial cells, fibroblasts, and mesothelial cells. Anti-CAV-1 is useful in assisting in the identification of epithelioid mesothelioma. A study by Amatya et al. indicates CAV-1 expression in all 80 (100%) epithelioid mesotheliomas, whereas only 6/80 (7.5%) of the lung adenocarcinomas were positive for CAV-1. Staining in most mesotheliomas was strong and diffuse when compared with the weak, focal staining (no more than 1% of the tumor cells) seen in the lung adenocarcinomas, anti-CAV-1 is considered a very useful marker for assisting in discriminating between these two malignancies. They also indicated that anti-CAV-1 is comparable to other mesothelioma markers such as anti-calretinin and anti-D2-40 (podoplanin) that are commonly used to assist in the differentiation between epithelioid mesotheliomas and lung adenocarcinomas. Anti-CAV-1 is also useful in identification of Ewing sarcoma/PNET. Literature indicates CAV-1 expression in 368 (96%) of 383 cases of Ewing sarcoma/PNET. In summary, anti-CAV-1 is very useful in the differentiation of epithelioid mesothelioma from lung adenocarcinoma and identification of Ewing sarcoma/PNET.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC







Caveolin-1 Positive Control Slides, Product No. 412S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Preparation Note

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Other Notes

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Safety & Documentation

Safety Information

NONH for all modes of transport


Certificate of Analysis (COA)

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Protocols & Articles


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412S Caveolin-1 Positive Control Slides, suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) 

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