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433R-1 Sigma-Aldrich

IMP3 (EP286) Rabbit Monoclonal Primary Antibody

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Properties

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Quality Level   100
  500
biological source   rabbit
antibody form   culture supernatant
antibody product type   primary antibodies
clone   EP286, monoclonal
description   (For In Vitro Diagnostic Use in Select Regions (See Chart))
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (433R-14)
  vial of 0.5 mL concentrate (433R-15)
  bottle of 1.0 mL predilute (433R-17)
  vial of 1.0 mL concentrate (433R-16)
  bottle of 7.0 mL predilute (433R-18)
mfr. no.   Cell Marque
concentration   1.0-10.0 μg/mL (predilute)
  25-250 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype   IgG
conjugate   unconjugated
control   pancreatic ductal adenocarcinoma, placenta
shipped in   wet ice
storage temp.   2-8°C
visualization   cytoplasmic, membranous

Description

General description

Insulin-like growth factor II mRNA binding protein 3 (IMP3) is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 and beta-actin. IMP3 expression is at its highest during embryogenesis and silenced in normal human tissues (fibroblasts, lymphocytes, and testes are exceptions).1 IMP3 plays a major role in early embryogenesis involving the development of the intestine, thymus, pancreas, and kidneys.2 IMP3 mRNA transcript and protein have been demonstrated in high levels in pancreatic cancer tissues but not in benign lesions of the pancreas, chronic pancreatitis, or normal pancreatic tissues.1 In a study of IMP3 being used to distinguish between pancreatic ductal adenocarcinoma from chronic sclerosing pancreatitis, IMP3 was found to have high sensitivity and specificity for pancreatic ductal adenocarcinoma and detected pancreatic ductal adenocarcinoma metastases.2 IMP3 expression has also been found in a variety of other human cancers including renal cell carcinoma, adenocarcinoma of the uterine cervix, endometrial carcinoma, adenocarcinoma of the esophagus, malignant melanoma, Merkel cell carcinoma, urothelial carcinoma, neuroendocrine carcinoma of the lung, adenocarcinoma of the pancreas, and triple negative breast cancer.1,2

Quality


IVD

IVD

IVD

RUO

Linkage

IMP3 Positive Control Slides, Product No. 433S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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