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  • 434R-1 - ERG (EP111) Rabbit Monoclonal Primary Antibody

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434R-1 Sigma-Aldrich

ERG (EP111) Rabbit Monoclonal Primary Antibody

  •  NACRES NA.41

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Properties

Related Categories Anatomic Pathology, Antibodies, Cell Marque Antibodies, Genitourinary (GU) Pathology, Primary Antibodies More...
Quality Level   100
  500
biological source   rabbit
antibody form   culture supernatant
antibody product type   primary antibodies
clone   EP111, monoclonal
description   (For In Vitro Diagnostic Use in Select Regions (See Chart))
form   buffered aqueous solution
species reactivity   human
packaging   vial of 0.1 mL concentrate (434R-14)
  vial of 0.5 mL concentrate (434R-15)
  bottle of 1.0 mL predilute (434R-17)
  vial of 1.0 mL concentrate (434R-16)
  bottle of 7.0 mL predilute (434R-18)
mfr. no.   Cell Marque
concentration   1.0-10.0 μg/mL (predilute)
  100-1000 μg/mL (concentrate)
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
isotype   IgG
conjugate   unconjugated
control   tonsil
shipped in   wet ice
storage temp.   2-8°C
visualization   nuclear

Description

General description

ERG is a member of the erythroblastosis virus E26 transforming sequence (ETS) transcription factor gene family, which also includes Fli-1 and ETS-1.1-5 ERG is expressed in lymphocytes and endothelial cells and regulates endothelial apoptosis and angiogenesis. ERG has been found to be expressed in both benign and malignant vascular tumors. Anti-ERG was found to have high sensitivity for vascular neoplasms.1 ERG expression has been observed in prostate carcinomas and high-grade prostatic intraepithelial neoplasia (HGPIN).1-4 ERG positivity in any other epithelial tumor other than prostate carcinoma is extremely rare. In a study of all carcinomas of the breast, gastrointestinal tract, gynecologic system, kidney, lung, ovary, pancreas, salivary glands, skin, thyroid, and testis were negative for ERG.1 ERG has also been observed to be positive in a minority of Ewing sarcomas.2 This is caused by a chromosomal rearrangement which fuses the EWSR1 gene with the ERG gene (EWSR 1:ERG).5 ERG has also been observed to stain some meningiomas due to cross reactivity with Fli-1.1

Quality


IVD

IVD

IVD

RUO

Linkage

ERG Positive Control Slides, Product No. 434S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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