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43794 Sigma-Aldrich

1,4-Dithioerythritol

BioUltra, ≥99.0% (RT)

Synonym: erythro-1,4-Dimercapto-2,3-butanediol, erythro-2,3-Dihydroxy-1,4-butanedithiol, Cleland’s reagent, DTE

  • CAS Number 6892-68-8

  • Linear Formula HSCH2CH(OH)CH(OH)CH2SH

  • Molecular Weight 154.25

  •  Beilstein/REAXYS Number 1719756

  •  EC Number 229-998-8

  •  MDL number MFCD00063750

  •  PubChem Substance ID 57650194

  •  NACRES NA.25

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Properties

Related Categories Alphabetical, BioUltra, Biochemicals and Reagents, Carbohydrates, Denaturation,
Quality Level   200
product line   BioUltra
assay   ≥99.0% (RT)
impurities   insoluble matter, passes filter test
  ≤0.5% 4,5-dihydroxy-1,2-dithiane
pH   4.0-6.0 (25 °C, 0.1 M in H2O)
mp   82-84 °C (lit.)
  82-85 °C
solubility   H2O: 0.1 M at 20 °C, clear, colorless
anion traces   sulfate (SO42-): ≤50 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.5 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤50 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
λ   0.1 M in H2O
UV absorption   λ: 260 nm Amax: 0.400
  λ: 280 nm Amax: 0.050
storage temp.   2-8°C
SMILES string   O[C@@H](CS)[C@H](O)CS
InChI   1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+
InChI key   VHJLVAABSRFDPM-ZXZARUISSA-N

Description

Application

Reagent for maintaining −SH groups in the reduced state; quantitatively reduces disulfides.

Other Notes

Cleavage of disulfide bonds in proteins; Prevents oxidation of sulfhydryl-containing proteins during SDS-polyacrylamide gel electrophoresis.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3335
WGK Germany 
WGK 3
RTECS 
KF2410000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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