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50046 Sigma-Aldrich

Glycine

BioUltra, for molecular biology, ≥99.0% (NT)

Synonym: Aminoacetic acid, Aminoethanoic acid, Glycocoll

  • CAS Number 56-40-6

  • Linear Formula NH2CH2COOH

  • Molecular Weight 75.07

  •  Beilstein Registry Number 635782

  •  EC Number 200-272-2

  •  MDL number MFCD00008131

  •  eCl@ss 32160406

  •  PubChem Substance ID 57651233

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Properties

Related Categories Alphabetical, Amino Acids, BioUltra, BioUltra Buffers, Biochemicals and Reagents,
grade   for molecular biology
InChI Key   DHMQDGOQFOQNFH-UHFFFAOYSA-N
product line   BioUltra
assay   ≥99.0% (NT)
form   crystalline
impurities   DNases, none detected
  RNases, none detected
  insoluble matter, passes filter test
  phosphatases, none detected
  proteases, none detected
ign. residue   ≤0.05% (as SO4)
loss   ≤0.05% loss on drying, HV, 20-26 °C
pKa (25 °C)   2.35
mp   240 °C (dec.) (lit.)
solubility   1 M HCl: 1 M at 20 °C, clear, colorless
anion traces   chloride (Cl-): ≤50 mg/kg
  sulfate (SO42-): ≤100 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  NH4+: ≤200 mg/kg
  Na: ≤100 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
λ   1 M in 1 M HCl
UV absorption   λ: 260 nm Amax: 0.05
  λ: 280 nm Amax: 0.05
Gene Information   rat ... Grin2a(24409)

Description

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Glycine is a non-essential amino acid. It is involved in the synthesis of purines, serine and porphyrins. Glycine-gated channels mediate the influx of calcium through cell membranes. It also acts as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. In cancer cells, the synthesis of glycine might be increased due to increased demand for the amino acid.

Packaging

1 kg in poly bottle

50, 250 g in poly bottle

Application

Glycine has been used as a component of the viral extraction mixture for adenovirus viral extraction.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
MB7600000
Protocols & Articles

Protocols

Correlative microscopy and electron tomography of GFP through photooxidation

Markus Grabenbauer a , Willie J C Geerts b , Julia Fernadez-Rodriguez c , Andreas Hoenger a , Abraham J Koster b , Tommy Nilsson c
Keywords: Apoptosis, Biochemistry, Catalysis, Catalytic combustion detector, Cell biology, Cell culture, Chromatin immunoprecipitation, Gene expression, Glycosylations, Microscopy, O-linked glycosylation, Oxidations, Polymerization reactions, Precipitation, Respiration, Scanning electron microscopy, Transfection, Transmission electron microscopy

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Peer-Reviewed Papers
15

References

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