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50118 Sigma-Aldrich

(4S)-4-Hydroxy-L-isoleucine

from fenugreek seed, ≥98.0% (TLC)

Synonym: (2S,3R,4S)-2-Amino-4-hydroxy-3-methylpentanoic acid, 4-HYDROXYISOLEUCINE, HIL

  • CAS Number 55399-93-4

  • Empirical Formula (Hill Notation) C6H13NO3

  • Molecular Weight 147.17

  •  Beilstein/REAXYS Number 4128096

  •  MDL number MFCD07357252

  •  eCl@ss 32160406

  •  PubChem Substance ID 329757568

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Properties

biological source   fenugreek seed
InChI Key   OSCCDBFHNMXNME-YUPRTTJUSA-N
assay   ≥98.0% (TLC)
optical activity   [α]/D +32.5±2.0°, c = 1 in H2O
storage temp.   2-8°C

Description

Biochem/physiol Actions

(4S)-4-Hydroxy-L-isoleucine (HIL) is a non-proteinogenic α amino acid produced by the activity of bacterial isoleucine dioxygenase(s). (2S,3R,4S)-HIL is being studied to understand its insulinotropic (anti-diabetic) and anti-obesity effects.

4-Hydroxyisoleucine (HIL) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secretion from pancreatic cells. HIL activates insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity. HIL reduces plasma levels of triglycerides, free fatty acids and cholesterol.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
296.6 °F
Flash Point(C) 
147 °C

Documents

Certificate of Analysis

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Protocols & Articles
Peer-Reviewed Papers
15

References

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