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50845 Sigma-Aldrich

Gramicidin A from Bacillus brevis

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics G-M,
biological source   Bacillus brevis
InChI Key   ZWCXYZRRTRDGQE-LUPIJMBPSA-N
form   powder or crystals
color   white to off-white
solubility   ethanol: soluble
Mode of action   cell membrane | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Amino Acid Sequence

HCO-X-Gly-L-Ala-D-Leu-L-Ala-D-Val-L-Val-D-Val-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-NHCH2CH2OH

Biochem/physiol Actions

Gramicidin A is a polypeptide antibiotic that forms single ion monovalent cation channels in biological membranes.

Gramicidin A increases the permeability of bacterial cell membranes, which allows inorganic monovalent cations to travel through unrestricted. This destroys the ion gradient between the cytoplasm and the extracellular environment . Gramicidin A acts as neutral carrier and helps in the establishment of ion flux across the lipid bilayer.

Packaging

100mg

Application

Gramicidin A is used for studies on bacterial cell wall permeabilization and monovalent cation channel formation. Gramicidin has also been shown to inhibit transcription of T7 phage DNA, inhibit membrane-bound epidennal adenosine triphosphatase, suppress human lymphocyte blastogenesis in vitro and prolong heart allograft survival in the rat model <REFERENCE ID="119564" TYPE="literature"/><REFERENCE ID="119563" TYPE="literature"/><REFERENCE ID="119614" TYPE="literature"/>. It has also been used to study its role in phospholipids adsorption during air-water interface.

General description

Chemical structure: peptide

Gramicidin A is a linear pentadecapeptide antibiotic produced by Bacillus brevis. The transmembrane protein contains a left-handed helix with alternating L and D residues.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Moisture sensitive. Store under inert gas. Keep in a dry place.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
MD8230000
Protocols & Articles
Peer-Reviewed Papers
15

References

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