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50981 Sigma-Aldrich

Guanidine thiocyanate

BioReagent, for molecular biology, ≥99%

Synonym: Guanidinium rhodanide, Guanidinium thiocyanate

  • CAS Number 593-84-0

  • Linear Formula NH2C(=NH)NH2 · HSCN

  • Molecular Weight 118.16

  •  Beilstein/REAXYS Number 3563461

  •  EC Number 209-812-1

  •  MDL number MFCD00013027

  •  PubChem Substance ID 57651291

  •  NACRES NA.52

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Properties

Related Categories Biochemicals and Reagents, Chaotropic Agents, Denaturation More...
Quality Level   200
biological source   synthetic
grade   for molecular biology
product line   BioReagent
assay   ≥99%
form   powder
application(s)   RNA extraction: suitable
impurities   DNases, none detected
  RNases, none detected
  phosphatases, none detected
  proteases, none detected
color   colorless to white,

mp   115-122 °C
  120-122 °C (lit.)
solubility   H2O: 4 M at 20 °C, clear, colorless
anion traces   chloride (Cl-): ≤5000 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Na: ≤5000 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
storage temp.   room temp
SMILES string   SC#N.NC(N)=N
InChI   1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H
InChI key   ZJYYHGLJYGJLLN-UHFFFAOYSA-N

Description

Application

Suitable for
• denaturation of macromolecules such as nucleic acids and proteins
• RNA isolation

Chaotropic agent and strong denaturant; solubilizes cells.

Packaging

100, 500 g in glass bottle

Principle

Guanidine thiocyanate interferes with the hydrogen bonds and intramolecular interactions of macromolecules. It solubilizes the proteins resulting in disintegration of cellular structures.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Supplemental Hazard Statements 
EUH032
Personal Protective Equipment 
RIDADR 
UN 1759 8 / PGIII
WGK Germany 
WGK 2
RTECS 
XL1225000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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