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53319 Sigma-Aldrich

L-Histidine

BioUltra, ≥99.5% (NT)

Synonym: (S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773

  • CAS Number 71-00-1

  • Empirical Formula (Hill Notation) C6H9N3O2

  • Molecular Weight 155.15

  •  Beilstein/REAXYS Number 84088

  •  EC Number 200-745-3

  •  MDL number MFCD00064315

  •  eCl@ss 32160406

  •  PubChem Substance ID 57651378

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Properties

Related Categories Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Amino Acids, Amino acids,
Quality Level   200
product line   BioUltra
assay   ≥99.5% (NT)
form   powder or crystals
optical activity   [α]20/D −39±1°, c = 2% in H2O
application(s)   detection: suitable
impurities   insoluble matter, passes filter test
  ≤0.5% foreign amino acids
ign. residue   ≤0.1% (as SO4)
loss   ≤0.5% loss on drying, 110 °C
color   white
pH   7.0-8.0 (25 °C, 0.1 M in H2O)
mp   282 °C (dec.) (lit.)
  ~285 °C (dec.)
solubility   H2O: 0.1 M at 20 °C, clear, colorless
anion traces   chloride (Cl-): ≤100 mg/kg
  sulfate (SO42-): ≤100 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  NH4+: ≤500 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
λ   0.1 M in H2O
UV absorption   λ: 260 nm Amax: 0.05
  λ: 280 nm Amax: 0.05
SMILES string   N[C@@H](Cc1c[nH]cn1)C(O)=O
storage temp.   room temp
InChI   1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChI key   HNDVDQJCIGZPNO-YFKPBYRVSA-N
Gene Information   human ... CA1(759), CA2(760)

Description

Application

L-Histidine has been used for characterization of ZnO nanorod in an attempt to develop a technique for the ultra-low level detection of l-histidine.

Biochem/physiol Actions

L-Histidine is involved in the one-carbon unit metabolism. It is associated with protein methylation. L-Histidine is a part of hemoglobin structure and function. L-Histidine is a component of dipeptides with antioxidative property. Histidine serves as a precursor for the formation of histamine, which is associated with allergic responses. Urocanic acid, an immune response modulator in skin is also biosynthesised from histidine.

Precursor of histamine by action of histidine decarboxylase.

Precursor of histamine by action of histidine decarboxylase.

Other Notes

Amino acid spacing in isotachophoresis on polyacrylamide gels - a critical evaluation; Prevents circular DNA strand cleavage in a xanthine-xanthine oxidase system; Growth requirement of various microorganisms.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
MS3070000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Related Content

Amino Acids Reference Charts

Amino acids are the compounds or building blocks that make up peptides and proteins. Each amino acid is structured from an amino group and a carboxyl group bound to a tetrahedral carbon. This carbon ...
Keywords: Building blocks, Gene expression, Mass spectrometry

Peer-Reviewed Papers
15

References

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