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53319 Sigma-Aldrich

L-Histidine

BioUltra, ≥99.5% (NT)

Synonym: (S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773

  • CAS Number 71-00-1

  • Empirical Formula (Hill Notation) C6H9N3O2

  • Molecular Weight 155.15

  •  Beilstein/REAXYS Number 84088

  •  EC Number 200-745-3

  •  MDL number MFCD00064315

  •  eCl@ss 32160406

  •  PubChem Substance ID 57651378

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Properties

Related Categories Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Amino Acids, Amino acids,
InChI Key   HNDVDQJCIGZPNO-YFKPBYRVSA-N
product line   BioUltra
assay   ≥99.5% (NT)
optical activity   [α]20/D −39±1°, c = 2% in H2O
impurities   insoluble matter, passes filter test
  ≤0.5% foreign amino acids
ign. residue   ≤0.1% (as SO4)
loss   ≤0.5% loss on drying, 110 °C
pH   7.0-8.0 (25 °C, 0.1 M in H2O)
mp   282 °C (dec.) (lit.)
  ~285 °C (dec.)
solubility   H2O: 0.1 M at 20 °C, clear, colorless
anion traces   chloride (Cl-): ≤100 mg/kg
  sulfate (SO42-): ≤100 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  NH4+: ≤500 mg/kg
  Na: ≤50 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
λ   0.1 M in H2O
UV absorption   λ: 260 nm Amax: 0.05
  λ: 280 nm Amax: 0.05
Gene Information   human ... CA1(759), CA2(760)

Description

Application

L-Histidine has been used for characterization of ZnO nanorod in an attempt to develop a technique for the ultra-low level detection of l-histidine.

Biochem/physiol Actions

L-Histidine is involved in the one-carbon unit metabolism. It is associated with protein methylation. L-Histidine is a part of hemoglobin structure and function. L-Histidine is a component of dipeptides with antioxidative property. Histidine serves as a precursor for the formation of histamine, which is associated with allergic responses. Urocanic acid, an immune response modulator in skin is also biosynthesised from histidine.

Precursor of histamine by action of histidine decarboxylase.

Precursor of histamine by action of histidine decarboxylase.

Other Notes

Amino acid spacing in isotachophoresis on polyacrylamide gels - a critical evaluation; Prevents circular DNA strand cleavage in a xanthine-xanthine oxidase system; Growth requirement of various microorganisms.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
MS3070000

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Related Content

Amino Acids Reference Chart

Amino acids are the 21 standard compounds or building blocks that make up peptides and proteins, including DNA. Each amino acid is structured from an amino group and a carboxyl group bound to a tetra...
Keywords: Building blocks, Gene expression, Mass spectrometry

Peer-Reviewed Papers
15

References

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