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55345 Sigma-Aldrich

N-Methyl-L-threonine

≥98% (TLC)

Synonym: (2S,3R)-3-Hydroxy-2-(methylamino)butyric acid, N-Me-Thr-OH

  • CAS Number 2812-28-4

  • Empirical Formula (Hill Notation) C5H11NO3

  • Molecular Weight 133.15

  •  Beilstein Registry Number 1722279

  •  MDL number MFCD02094308

  •  PubChem Substance ID 329757944

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Properties

InChI Key   CCAIIPMIAFGKSI-DMTCNVIQSA-N
assay   ≥98% (TLC)
optical activity   [α]/D -24.0±1.0°, c = 1 in 1 M HCl
composition   carbon, 44.2-46.0%
  nitrogen, 10.3-10.8%
storage temp.   2-8°C

Description

Biochem/physiol Actions

N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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