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  • 56720 - Ibotenic acid monohydrate from Amanita sp.

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56720 Sigma-Aldrich

Ibotenic acid monohydrate from Amanita sp.

≥99.0% (TLC)

Synonym: α-(3-Hydroxy-5-isoxazolyl)glycine, α-Amino-2,3-dihydro-3-oxo-5-isoxazoleacetic acid, α-Amino-3-hydroxy-5-isoxazoleacetic acid

  • CAS Number 60573-88-8

  • Empirical Formula (Hill Notation) C5H6N2O4 · H2O

  • Molecular Weight 176.13

  •  Beilstein/REAXYS Number 1075440

  •  MDL number MFCD00150903

  •  PubChem Substance ID 24880352

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Properties

InChI Key   QVKQQLYSTODTJN-UHFFFAOYSA-N
assay   ≥99.0% (TLC)
mp   148-151 °C
solubility   1 M NH4OH: 50 mg/mL, clear, colorless to yellow

Description

Biochem/physiol Actions

Ibotenic acid, a 3-isoxazolol amino acid, is an AMPA subtype glutamate receptor agonist involved in signal activation and blockade. Ibotenic acid from mushrooms such as Amanita muscaria and pantherina is an inducer of the “pantherina” central nervous system poisoning syndrome.

Ibotenic acid, a mushroom chemical neurotoxin, is used alone and together with factors such as β-amyloid(25-35) to induce neurotoxic lesions in the brain.

Other Notes

Review; Studies on the glutamate receptor

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGIII
WGK Germany 
3
RTECS 
NY2100000

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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