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61350 Sigma-Aldrich

TS-Link Bimane thiosulfate sodium salt

≥98.0% (HPCE)

Synonym: Thiosulfuric acid S-{2-oxo-2-{[(2,5,6-trimethyl-1,7-dioxo-1H,7H-pyrazolo[1,2-a]pyrazol-3-yl)methyl]amino}ethyl}ester monosodium salt

  • CAS Number 852178-18-8

  • Empirical Formula (Hill Notation) C12H14N3NaO6S2

  • Molecular Weight 383.38

  •  MDL number MFCD12912387

  •  PubChem Substance ID 329759443

  •  NACRES NA.32

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Properties

Related Categories Biochemicals and Reagents, Luminescent Compounds/Detection, Stains and Dyes More...
Quality Level   100
assay   ≥98.0% (HPCE)
fluorescence   λex 386 nm; λem 480 nm in 0.1 M phosphate pH 7.0
suitability   corresponds for coupling to thiols
storage temp.   −20°C
SMILES string   [Na+].CC1=C(C)C(=O)N2N1C(CNC(=O)CSS([O-])(=O)=O)=C(C)C2=O
InChI   1S/C12H15N3O6S2.Na/c1-6-8(3)14-9(7(2)12(18)15(14)11(6)17)4-13-10(16)5-22-23(19,20)21;/h4-5H2,1-3H3,(H,13,16)(H,19,20,21);/q;+1/p-1
InChI key   CFJHROSVZGHNCG-UHFFFAOYSA-M

Description

Application

TS-Link Bimane thiosulfate sodium salt is used to fluorescence label sulfhydryls found in proteins and other biomolecules such as glutathione. In contrast to the thioether bonds formed by maleimides and iodoacetamides, the disulfide bonds formed by TS-Link reagents are reversible — the TS-Link hapten or fluorophore can easily be removed using a reducing agent such as DTT or TCEP. TS-Link reagents are selective for thiols at neutral pH, whereas maleimides will react with other functional groups. TS-Link Bimane thiosulfate sodium salt may be used in comparison with other sulfhydryl coupling strategies.

Legal Information

TS-Link is a trademark of Life Technologies

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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