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71736 Sigma-Aldrich

Sodium dodecyl sulfate solution

BioUltra, for molecular biology, 10% in H2O

Synonym: Lauryl sulfate sodium salt, SDS, Sodium lauryl sulfate solution

  • CAS Number 151-21-3

  • Linear Formula CH3(CH2)11OSO3Na

  • Molecular Weight 288.38

  •  Beilstein/REAXYS Number 3599286

  •  MDL number MFCD00036175

  •  eCl@ss 39093306

  •  PubChem Substance ID 57652355

  •  NACRES NA.26



Related Categories Alkyl Sulfates, Alphabetical, Anionic Detergents, Antigen-Vaccine Preparation, BioUltra,
Quality Level   200
grade   for molecular biology
description   anionic
product line   BioUltra
mol wt   288.38 g/mol
concentration   10% in H2O
application(s)   HPLC: suitable
  protein quantification: suitable
impurities   DNases, none detected
  RNases, none detected
  insoluble matter, passes filter test
  phosphatases, none detected
  proteases, none detected
pH   5.0-6.5
density   1.01 g/mL at 20 °C
anion traces   chloride (Cl-): ≤50 mg/kg
  phosphate (PO43-): ≤1 mg/kg
cation traces   Al: ≤1 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤1 mg/kg
  Bi: ≤1 mg/kg
  Ca: ≤5 mg/kg
  Cd: ≤1 mg/kg
  Co: ≤1 mg/kg
  Cr: ≤1 mg/kg
  Cu: ≤1 mg/kg
  Fe: ≤1 mg/kg
  K: ≤20 mg/kg
  Li: ≤1 mg/kg
  Mg: ≤1 mg/kg
  Mn: ≤1 mg/kg
  Mo: ≤1 mg/kg
  Ni: ≤1 mg/kg
  Pb: ≤1 mg/kg
  Sr: ≤1 mg/kg
  Zn: ≤1 mg/kg
λ   neat
UV absorption   λ: 260 nm Amax: 0.3
  λ: 280 nm Amax: 0.2
SMILES string   [Na+].CCCCCCCCCCCCOS([O-])(=O)=O
InChI   1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1



Sodium dodecyl sulfate solution has been used:
• in the preparation of 2x extraction buffer
• as a component in elution buffer for immunoprecipitation
• in SDS–polyacrylamide gel electrophoresis (PAGE) analysis

Biochem/physiol Actions

Sodium dodecyl sulfate (SDS)/lauryl sulfate, is an ionic detergent has the ability to disrupt biological membranes. It can block ribonuclease (RNase) and deoxyribonuclease (DNase) activity. SDS is one of the main constituents of several reagents, that are used to purify nucleic acids. It is also considered as a permeability enhancer in oral formulations.

Other Notes

In large-scale phenol extraction of RNA - promotes the dissociation of protein from nucleic acids when extracting from biological material

Safety & Documentation

Safety Information

GHS07  GHS07
Signal word 
Hazard statements 
Precautionary statements 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles


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