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72309 Sigma-Aldrich

Nicotinic acid

≥99.5% (HPLC)

Synonym: 3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3

  • CAS Number 59-67-6

  • Empirical Formula (Hill Notation) C6H5NO2

  • Molecular Weight 123.11

  •  Beilstein/REAXYS Number 109591

  •  EC Number 200-441-0

  •  MDL number MFCD00006391

  •  PubChem Substance ID 57652411

  •  NACRES NA.26

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Properties

Related Categories Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Armoracia rusticana (Horseradish), Artemisia vulgaris,
biological source   synthetic
assay   ≥99.5% (HPLC)
form   powder
application(s)   cell culture | mammalian: suitable
impurities   ≤0.2% water
ign. residue   ≤0.05%
color   colorless to white
mp   234-238 °C
  236-239 °C (lit.)
solubility   water: 0.1 g/10 mL, clear, colorless
density   1.473 g/cm3 at 25 °C
storage temp.   room temp
SMILES string   OC(=O)c1cccnc1
InChI   1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
InChI key   PVNIIMVLHYAWGP-UHFFFAOYSA-N
Gene Information   human ... CYP1A2(1544)
rat ... Chrnb2(54239)

Description

General description

Nicotinic acid, also referred as Niacin or vitamin B3, is a water soluble vitamin. It is present in vitamin-enriched bread, liver, meat, fish, poultry, potatoes, green vegetables, peanuts and cereals.

Application

Nicotinic acid has been used as a standard in NAD+ precursor rescue experiments. It has also been used as a vitamin supplement in various culture media such as complete medium (CM) and synthetic medium.

Biochem/physiol Actions

Nicotinic acid or Niacin regulates lipid metabolism by reducing low density lipoprotein (LDL), increasing high-density lipoprotein (HDL) and by inhibiting the progression of atherosclerosis and coronary artery lesions. Niacin deficiency leads to pellagra. In addition to vitamin supplement, niacin is also used as a broad spectrum lipid drug.

Other Notes

Coenzyme and Cofactors, vol 2: Pyridine Nucleotide Coenzymes

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
QT0525000
Flash Point(F) 
379.4 °F - closed cup
Flash Point(C) 
193 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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