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74667 Sigma-Aldrich

Nourseothricin sulfate

≥85% (HPLC)

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application,
Quality Level   100
biological source   Streptomyces noursei
assay   ≥85% (HPLC)
form   solid
color   white to light brown
solubility   H2O: soluble 200 mg/mL
suitability   suitable for (selection agent for molecular genetic research work)
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  fungi
  mycobacteria
  mycoplasma
  parasites
  viruses
  yeast
storage temp.   2-8°C

Description

General description

Chemical structure: peptidyl nucleoside

Application

Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.

Biochem/physiol Actions

Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.

Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.

Packaging

10mg, 100mg

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
RD4240000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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