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78830 Sigma-Aldrich

Phenylmethanesulfonyl fluoride

≥99.0% (T)

Synonym: α-Toluenesulfonyl fluoride, Benzylsulfonyl fluoride, PMSF, Phenylmethylsulfonyl fluoride

  • CAS Number 329-98-6

  • Empirical Formula (Hill Notation) C7H7FO2S

  • Molecular Weight 174.19

  •  Beilstein/REAXYS Number 2088311

  •  EC Number 206-350-2

  •  MDL number MFCD00007424

  •  PubChem Substance ID 57652759

  •  NACRES NA.77

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Properties

Related Categories Biochemicals and Reagents, Core Bioreagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates,
biological source   synthetic
assay   ≥99.0% (T)
form   powder or crystals
impurities   ≤0.1% water
mp   92-95 °C
solubility   anhydrous isopropanol: soluble 35 mg/mL, clear to faintly hazy, colorless to faintly yellow (Heating required)
storage temp.   room temp
SMILES string   FS(=O)(=O)Cc1ccccc1
InChI   1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChI key   YBYRMVIVWMBXKQ-UHFFFAOYSA-N

Description

Application

Phenylmethanesulfonyl fluoride has been used as a component in radioimmunoprecipitation buffer for western blot analysis. It has also been used as a component in the RAW264.7 cell lysis buffer for western blotting.

Biochem/physiol Actions

Phenylmethanesulfonyl fluoride has the ability to enhance the stability of plasma lipidome in lipidomic and metabolomic analysis. This serine protease inhibitor reduces the naloxone-precipitated withdrawal jumping behavior in morphine-dependent mice.

Other Notes

Specific trypsin and chymotrypsin inhibitor. Less toxic substitute for diisopropylfluorophosphate. Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C.

Specific trypsin and chymotrypsin inhibitor; Less toxic substitute for diisopropylfluorophosphate. Potentiates the effects of ischemia on brain mitochondria through its inhibition of phospholipase C.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN 2928 8(6.1) / PGII
WGK Germany 
WGK 3
RTECS 
XT8040000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Single- & multi-channel pipettes from BRAND
Protocols & Articles
Peer-Reviewed Papers
15

References

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