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  • 79346 - Phorbol 12-myristate 13-acetate

79346 Sigma-Aldrich

Phorbol 12-myristate 13-acetate

synthetic, ≥98.0% (TLC)

Synonym: 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate, PMA, TPA

  • CAS Number 16561-29-8

  • Empirical Formula (Hill Notation) C36H56O8

  • Molecular Weight 616.83

  •  Beilstein/REAXYS Number 2407201

  •  MDL number MFCD00036736

  •  PubChem Substance ID 57652787



assay   ≥98.0% (TLC)
quality   synthetic
solubility   chloroform: 10 mg/mL, clear, colorless to light yellow
storage temp.   −20°C



Phorbol 12-myristate 13-acetate has been used to stimulate the in vitro production of interleukin (IL)-18, IL-10 and macrophages. It has also been used to induce protein kinase C activity.


1, 5, 25 mg in glass bottle

Biochem/physiol Actions

Phorbol 12-myristate 13-acetate is a potent tumor promoter and activates protein kinase C in vivo and in vitro. It is a phorbol ester that is associated with many cellular responses including gene transcription, cell division and differentiation, apoptosis and immune response. It is also involved in protein kinase C (PKC) mediated receptor desensitization. Phorbol 12-myristate 13-acetate induces PKC localization from the cytosol, enabling the enzyme association with the cell membrane.

Potent tumor promoter; activates protein kinase C in vivo and in vitro.

Other Notes

Activates protein kinase C in vivo and in vitro at nanomolar concentrations; Highly potent tumor promotor and mitogen: active principle of croton oil. Review

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 


Certificate of Analysis


Certificate of Origin


Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How shouldProduct 79346, Phorbol 12-myristate 13-acetate - synthetic, be dissolved?
PMA is soluble in acetone, DMSO, ethyl acetate, ethanol and methylene chloride, but is practically insoluble in water. The solubility of 79346 has been tested in chloroform at a concentration of 10 mg/mL.Stock solutions of 20 mM can be prepared in DMSO and diluted into aqueous buffers.
Why do I not see any solid in the bottle of Product 79346, Phorbol 12-myristate 13-acetate - synthetic?
Phorbol 12-myristate 13-acetate may be an invisible film in the bottle.
What is the difference between product 79346, Phorbol 12-myristate 13-acetate - synthetic,and molecular biology grade product P1585?
Product P1585 has been tested and found suitable for stimulation of interleukin 2 production of Jurkat cells. Product 79346 has not tested in this application.
How can I store theProduct 79346, Phorbol 12-myristate 13-acetate - synthetic (PMA), solution solution?How long?
Stock solutions in DMSO can be stored protected from light as aliquots at -20°C for at least 6 months, or at 2-8°C for up to 3 months.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Protocols & Articles


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BioFiles 2008, 3.5, 18.
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