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79852 Sigma-Aldrich

Cryptotanshinone

≥90% (HPLC)

Synonym: (R)-(−)-1,6,6-Trimethyl-1,2,6,7,8,9-hexahydrophenanthro[1,2-b]furan-10,11-dione, Tanshinone C

  • CAS Number 35825-57-1

  • Empirical Formula (Hill Notation) C19H20O3

  • Molecular Weight 296.36

  •  Beilstein/REAXYS Number 5445400

  •  MDL number MFCD07636810

  •  PubChem Substance ID 329768656

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Properties

Related Categories A - K, Aerobic Glycolysis (the Warburg Effect), Antibacterial, Antibiotics, Antibiotics A to Z,
InChI Key   GVKKJJOMQCNPGB-JTQLQIEISA-N
assay   ≥90% (HPLC)
optical activity   [α]/D -85.0±3.0°, c = 0.1 in chloroform
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

Description

Application

Cryptotanshinone (CPT), a lipophilic diterpene derived from the roots of Salvia miltiorrhiza Bge and Salvia przewalskii Maxim, may be used to study its multiple bioactivities as an antibacterial, antidermatophytic, antioxidant, anti-inflammatory and anticancer agent. Cryptotanshinone may also be studied as a differentiation factor.

Biochem/physiol Actions

Cryptotanshinone is an antibacterial and anti-inflammatory compound originally extracted from the roots of Salvia miltiorrhiaz (danshen). Cryptotanshinone has been found to inhibit HIF activation and to inhibit macrophage migration negatively regulate the PI3K pathway. It has demonstrated activity against several strains of Staphylococcus aureus.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
SF8282645

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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