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85580 SAFC

Spermidine trihydrochloride

≥99.0% (AT)

Synonym: N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride

  • CAS Number 334-50-9

  • Linear Formula NH2(CH2)3NH(CH2)4NH2 · 3HCl

  • Molecular Weight 254.63

  •  Beilstein/REAXYS Number 3552356

  •  EC Number 206-379-0

  •  MDL number MFCD00012918

  •  PubChem Substance ID 329769390

  •  NACRES NA.77

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Substrate Analogs More...
Quality Level   200
biological source   microbial
  synthetic
assay   ≥99.0% (AT)
mp   ~250 °C (dec.)
  257-259 °C (lit.)
solubility   H2O: 0.1 g/mL, clear, colorless
storage temp.   room temp
SMILES string   Cl[H].Cl[H].Cl[H].NCCCCNCCCN
InChI   1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H
InChI key   LCNBIHVSOPXFMR-UHFFFAOYSA-N

Description

General description

Spermidine is a polyamine and a trivalent organic cation.

Application

Spermidine trihydrochloride has been used as standard for the detection of biogenic amines using HPLC.

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Spermidine modulates various cellular activities like cellular development and differentiation, stability of DNA and apoptosis.

Caution

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
EJ7023000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Sensor Dyes

In 1998 R.F. Furchgott, L.J. Ignarro, and F. Murad received the Nobel Prize in Physiology and Medicine for their discoveries concerning nitric oxide as a signaling molecule in the cardiovascular syst...
Monika Baeumle
BioFiles 2011, 6.3, 23.
Keywords: Applications, Biochemistry, Biological processes, Cancer, Cardiovascular, Central Nervous System, Diseases, Extinction coefficient, Indicators, Inflammation, Methods, Microscopy, Neurotransmission, Sol-gel, Type

Peer-Reviewed Papers
15

References

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