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2,5-Dihydroxybenzoic acid

matrix substance for MALDI-MS, >99.0% (HPLC)

Synonym: 2,5-DHBA, DHB, Gentisic acid, Hydroquinonecarboxylic acid

  • CAS Number 490-79-9

  • Linear Formula (HO)2C6H3CO2H

  • Molecular Weight 154.12

  •  Beilstein/REAXYS Number 2209119

  •  EC Number 207-718-5

  •  MDL number MFCD00002460

  •  PubChem Substance ID 329769406

  •  NACRES NA.21

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Properties

Related Categories Analytical Reagents, Analytical/Chromatography, Glycan Labeling and Analysis, Glycobiology, Mass Spectrometry (MS),
grade   matrix substance for MALDI-MS
assay   >99.0% (HPLC)
analyte functional class(es)   polymers
analyte chemical class(es)   glycans, lipids, organic molecules, peptides, proteins
application(s)   MALDI-MS: suitable
mp   200-207 °C
  204-208 °C (lit.)
cation traces   Ba: ≤5 mg/kg
  Ca: ≤5 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  K: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Na: ≤5 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Zn: ≤5 mg/kg
ε (extinction coefficient)   >2000 at 337 nm
storage temp.   room temp
SMILES string   OC(=O)c1cc(O)ccc1O
InChI   1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)
InChI key   WXTMDXOMEHJXQO-UHFFFAOYSA-N

Description

Application

2,5-Dihydroxybenzoic acid is an ionic liquid matrix used for the analysis of biomolecules using matrix-assisted laser desorption/ionization combined with mass spectrometry.

Most commonly used matrix for carbohydrates. For MALDI-MS of free neutral glycans. Produces [M+Na]+ ion; may show a weaker [M+K]+ ion. Other species may be generated by the addition of the appropriate inorganic salt.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
LY3850000
Protocols & Articles

Articles

Mass Spectrometry of Glycans

The development of modern mass spectrometry (MS) equipment with high resolution and mass accuracy has led to its use in analyzing glycans for both profiling and structural studies. Unlike the HPLC me...
Glycobiology Analysis Manual, 2nd Edition
Keywords: Catalysis, Centrifugation, High performance liquid chromatography, Mass spectrometry, Phase transitions, Proteomics, Reductions, Sample preparations, Sequencing

Methods and matrices for mass spectrometry of glycans

Glycosylation is known to have profound influence on various physiochemical, cellular and biological functions of proteins. Alterations in this modification are known to affect the immune system and ...
BioFiles v5 n1
Keywords: Addition reactions, Cancer, Capillary electrophoresis, Chromatography, Derivatizations, Digestions, Diseases, Electrophoresis, Eliminations, Fermentation, Filtration, Gas chromatography, Glycosylations, High performance liquid chromatography, Ion Exchange, Liquid chromatography mass spectrometry, Mass spectrometry, PAGE, Phase transitions, Proteomics, Purification, Sequencing

Peer-Reviewed Papers
15

References

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