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88185 Sigma-Aldrich

Tetrazole solution

for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile

  • CAS Number 288-94-8

  • Empirical Formula (Hill Notation) CH2N4

  • Molecular Weight 70.05

  •  Beilstein/REAXYS Number 105799

  •  MDL number MFCD00005247

  •  PubChem Substance ID 57653295

  •  NACRES NA.21

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Properties

Related Categories Chemical Biology, Chemical Synthesis, Coupling Reagents, Nucleoside Chemistry
Quality Level   300
grade   for DNA synthesis
quality   filtered through a 1 μm filter
concentration   ~0.45 M in acetonitrile
impurities   ≤0.003% water
bp   84 °C (lit.)
mp   156-158 °C (lit.)
density   0.798 g/mL at 20 °C
SMILES string   c1nnn[nH]1
InChI   1S/CH2N4/c1-2-4-5-3-1/h1H,(H,2,3,4,5)
InChI key   KJUGUADJHNHALS-UHFFFAOYSA-N

Description

General description

The product is ~0.45M solution of tetrazole in acetonitrile. Tetrazole ring plays significant role in various synthetic and industrial processes.

Application

Tetrazole solution is useful for DNA synthesis. It may be employed as a catalyst for the in situ synthesis of deoxyribonucleoside phosphoramidites. It may be used in the preparation of following anionic nucleotide-lipids:
• thymidine 3′-(1,2-dilauroyl-sn-glycero-3-phosphate) , diC12-3′-dT
• thymidine 3′-(1,2-dimyristoyl-sn-glycero-3-phosphate) diC14- 3′-dT
• thymidine-3′-(1,2-dipalmitoyl-sn-glycero-3-phosphate) diC16- 3′-dT

Packaging

100, 500 mL in Sure/Seal™

Caution

Saturated solution at room temperature; storage below room temperature causes precipitation.

Other Notes

Catalyst used in the phosphite triester method of oligonucleotide synthesis for the coupling of (dialkylamino)phosphines

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN1993 - class 3 - PG 2 - Tetrazol solution flammable liquids, n.o.s., HI: all
WGK Germany 
WGK 3
Flash Point(F) 
41.0 °F - closed cup
Flash Point(C) 
5 °C - closed cup

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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