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89510 Sigma-Aldrich

Poly(ethylene glycol)

BioUltra, 8,000

Synonym: PEG

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Properties

Related Categories Essential Chemicals, Materials Science, Molecular Biology, Optimization Reagents, PEG and Oligo Ethylene Glycol,
Quality Level   200
product line   BioUltra
form   solid
mol wt   Mr 7000-9000
impurities   insoluble matter:, passes filter test
  ≤0.001% peroxides (as H2O2):
pH   5.5-7.0 (25 °C, 50 mg/mL in H2O)
mp   61-64 °C
solubility   H2O: 50 mg/mL at 25 °C, clear, colorless
anion traces   chloride (Cl-): ≤50 mg/kg
  sulfate (SO42-): ≤50 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤200 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  Na: ≤200 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
λ   50 mg/mL in H2O
UV absorption   λ: 260 nm Amax: 0.09
  λ: 280 nm Amax: 0.03
InChI   1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2
InChI key   LYCAIKOWRPUZTN-UHFFFAOYSA-N

Description

General description

Poly(ethylene glycol) (PEG) is a polymer of ethylene glycol units and is hydrophilic in nature. PEG has high hydration capacity and is structurally flexible. PEG has advantage as a drug conjugate due to biocompatibility and nonexistence of steric hindrances in its structure.

Application

Poly(ethylene glycol) has been used:
• in the transformation buffer in yeast
• as a constituent of dengue virus isolation buffer
• for concentration of lentivirus particles
• in the crystallization of herpesvirus nuclear egress complex (NEC)

Biochem/physiol Actions

The Food and Drug Administration (FDA) approved PEG as drug conjugates, is nonimmunogenic and safe. PEG is widely used as a reagent in biochemistry and molecular biology experiments. PEG conjugation improves solubility and dissolution of diabetes drug, Gliclazide. It is used in carbon nanotube functionalization. The presence of PEG 8000 in the tannin tree foliage improves metabolisable energy (ME) content and gas production.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Single- & multi-channel pipettes from BRAND
Protocols & Articles

Articles

Polyethylene Glycol (PEG) Selection Guide

Poly(ethylene glycol) (PEG) is a synthetic, hydrophilic, biocompatible polymer with widespread use in biomedical and other applications. PEGs are synthesized using a ring-opening polymerization of et...
Keywords: Adhesion, Bacterial conjugations, Click chemistry, Molecular biology, PEGylations, Polymerization reactions, Ring-opening polymerization

Peer-Reviewed Papers
15

References

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