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  • 90182 - Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride

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90182 Sigma-Aldrich

Nα-Tosyl-L-lysine chloromethyl ketone hydrochloride

≥99.0% (AT)

Synonym: (3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride, (3S)-7-Amino-1-chloro-3-tosylamino-2-heptanone hydrochloride, TLCK, Tosyl-L-lysyl-chloromethane hydrochloride

  • CAS Number 4272-74-6

  • Empirical Formula (Hill Notation) C14H21ClN2O3S · HCl

  • Molecular Weight 369.31

  •  Beilstein/REAXYS Number 7106867

  •  EC Number 224-266-4

  •  MDL number MFCD00065395

  •  eCl@ss 32160406

  •  PubChem Substance ID 57653369

  •  NACRES NA.77

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Properties

Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Organic Covalent Modifiers More...
Quality Level   100
biological source   synthetic
assay   ≥99.0% (AT)
form   powder or crystals
optical activity   [α]20/D −7.8±0.5°, c = 2% in H2O
storage temp.   −20°C
SMILES string   Cl[H].Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl
InChI   1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
InChI key   YFCUZWYIPBUQBD-ZOWNYOTGSA-N

Description

Other Notes

An alkylating reagent that may react with histidine or cysteine residues at the active site of enzymes. Inactivates serine proteases such as trypsin and clostripain . Chymotrypsin is not affected. To prevent proteolytic degradation, a combination of TLCK and TPCK can be used throughout the isolation of proteins, as in the isolation of histones.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
XT5160000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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