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93829 Sigma-Aldrich

L-Tyrosine

BioUltra, ≥99.0% (NT)

Synonym: (S)-2-Amino-3-(4-hydroxyphenyl)propionic acid, 3-(4-Hydroxyphenyl)-L-alanine

  • CAS Number 60-18-4

  • Linear Formula 4-(HO)C6H4CH2CH(NH2)CO2H

  • Molecular Weight 181.19

  •  Beilstein/REAXYS Number 392441

  •  EC Number 200-460-4

  •  MDL number MFCD00002606

  •  eCl@ss 32160406

  •  PubChem Substance ID 57653577

  •  NACRES NA.26

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Properties

Related Categories Amino Acids, Amino acids, BioUltra, Biochemicals and Reagents, Cell Biology,
Quality Level   200
product line   BioUltra
assay   ≥99.0% (NT)
form   powder or crystals
optical activity   [α]20/D −11.5±1.0°, c = 4% in 1 M HCl
application(s)   ligand binding assay: suitable
impurities   insoluble matter, passes filter test
  ≤0.5% foreign amino acids
ign. residue   ≤0.1%
loss   ≤0.2% loss on drying, 20 °C (HV)
color   white
mp   >300 °C (dec.) (lit.)
solubility   1 M HCl: 25 mg/mL, clear, colorless (hot)
anion traces   chloride (Cl-): ≤400 mg/kg
  sulfate (SO42-): ≤300 mg/kg
cation traces   Al: ≤5 mg/kg
  As: ≤0.1 mg/kg
  Ba: ≤5 mg/kg
  Bi: ≤5 mg/kg
  Ca: ≤10 mg/kg
  Cd: ≤5 mg/kg
  Co: ≤5 mg/kg
  Cr: ≤5 mg/kg
  Cu: ≤5 mg/kg
  Fe: ≤5 mg/kg
  K: ≤50 mg/kg
  Li: ≤5 mg/kg
  Mg: ≤5 mg/kg
  Mn: ≤5 mg/kg
  Mo: ≤5 mg/kg
  NH4+: ≤200 mg/kg
  Na: ≤200 mg/kg
  Ni: ≤5 mg/kg
  Pb: ≤5 mg/kg
  Sr: ≤5 mg/kg
  Zn: ≤5 mg/kg
absorption   cut-off at 310 nm in 1 M HCl at 0.5 M
SMILES string   N[C@@H](Cc1ccc(O)cc1)C(O)=O
InChI   1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1
InChI key   OUYCCCASQSFEME-QMMMGPOBSA-N

Description

Application

L-Tyrosine was used in tyrosine hydroxylase (TH) enzyme activity assay. It was also used as a substrate for tyrosinase enzyme in the growth media of Vibrio cholerae strains to stimulate melanin formation. It may be used as a precursor in the synthesis of (-)-MY 336a. MY 336a, a β-adrenergic receptor antagonist, was initially isolated from the culture broth of Streptomyces gabonae KY2234 (ATCC 15282). It may be used in the synthesis of 3-bromo-L-tyrosine and 3,5-dibromo-L-tyrosine.

Other Notes

Amino acid precursor of dopamine and other catecholamines

Growth requirements of various microorganisms

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
YP2275600
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Characteristic Metabolites for Inborn Errors of Amino Acid Metabolism

Inborn errors of metabolism are caused by changes in specific enzymatic reactions and hundreds of different such alterations, which affect about 1 of every 5000 newborns, have been characterized. The...
Keywords: Indicators, Metabolism, Metabolites

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Related Content

Amino Acids Reference Charts

Amino acids are the compounds or building blocks that make up peptides and proteins. Each amino acid is structured from an amino group and a carboxyl group bound to a tetrahedral carbon. This carbon ...
Keywords: Building blocks, Gene expression, Mass spectrometry

Peer-Reviewed Papers
15

References

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