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94577 Sigma-Aldrich

DL-α-Hydroxyglutaric acid disodium salt

≥95.0% (GC)

Synonym: (RS)-2-Hydroxypentanedioic acid disodium salt, Disodium 2-hydroxyglutarate

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Properties

InChI Key   DZHFTEDSQFPDPP-UHFFFAOYSA-L
assay   ≥95.0% (GC)
impurities   ≤6.0% water
storage temp.   2-8°C
  2-8°C

Description

Biochem/physiol Actions

D-(or R-) enantiomer of α-hydroxyglutaric acid is a cancer related biomarker of diagnostic value, whereas the L-(or S-) enantiomer of α-hydroxyglutaric acid is a biomarker for certain neurometabolic, inherited disorder diseases. It has no known physiological function in eukaryotes. It is toxic to the brain and increases the susceptibility to develop brain tumors.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Protocols & Articles

Articles

Chiral LC-MS/MS of D- and L-2-Hydroxyglutaric Acid Biomarkers

Chiral 2-hydroxyglutarates (2-OHG) are important molecular signatures of their specific biochemical pathways and inborn errors of metabolism, for both healthy and diseased biological cells. For examp...
Roland Wöhlgemuth, Rudolf Köhling, Hugh Cramer
Reporter Volume 31.3
Keywords: Asymmetric synthesis, Cancer, Citric Acid Cycle, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Metabolites, Phase transitions, Reductions, Separation

LC/MS (TOF) Analysis of DL-α-Hydroxyglutaric Acid Enantiomers on Astec® CHIROBIOTIC® R, Fast Separation

From our library of Articles, Sigma-Aldrich presents LC/MS (TOF) Analysis of DL-α-Hydroxyglutaric Acid Enantiomers on Astec® CHIROBIOTIC® R, Fast Separation
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Separation

New Metabolomics Products

The availability of metabolites is an important element for progress in metabolomics. We have expanded our collection in an effort to provide you with the metabolites needed to advance your research.
Keywords: Metabolites, Metabolomics

Peer-Reviewed Papers
15

References

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