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A0231 Sigma-Aldrich

AS 604850

≥98% (HPLC), solid

Synonym: 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI3Kγ inhibitor

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Properties

Related Categories AN-AZ, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   SRLVNYDXMUGOFI-YWEYNIOJSA-N
assay   ≥98% (HPLC)
form   solid
color   off-white
solubility   DMSO: >10 mg/mL
  H2O: <2 mg/mL
shipped in   wet ice
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

AS 604850 is a selective PI3Kγ inhibitor

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction

Phosphoinositide Kinases

The membranes of all metazoan cells contain a substantial amount of phosphatidylinositol (PtdIns) and at least seven phosphorylated PtdIns derivatives (PPIn) at 30- to 1000-fold lower concentrations....
Keywords: Cancer, Catalysis, Gene expression, Genetic, Growth factors, Phosphorylations

Peer-Reviewed Papers
15

References

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