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A0781 Sigma-Aldrich

Aphidicolin from Nigrospora sphaerica

≥98% (HPLC), powder

Synonym: APC

  • CAS Number 38966-21-1

  • Empirical Formula (Hill Notation) C20H34O4

  • Molecular Weight 338.48

  •  Beilstein/REAXYS Number 4689958

  •  MDL number MFCD00083214

  •  PubChem Substance ID 57653817

  •  NACRES NA.77

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Properties

Related Categories AN-AZ, Antibiotics, Antibiotics A to Z, Antibiotics by Application, Antibiotics by Mechanism of Action,
Quality Level   300
assay   ≥98% (HPLC)
form   powder
optical activity   [α]27/D +12°, c = 1 in methanol(lit.)
color   white
mp   227-233 °C (lit.)
solubility   ethanol: 1 mg/mL (stable at least a week at 4°C.)
  DMSO: 10 mg/mL (stable at least six weeks at −20°C.)
  methanol: 10 mg/mL
  H2O: insoluble
Mode of action   DNA synthesis | interferes
antibiotic activity spectrum   neoplastics
  viruses
storage temp.   2-8°C
SMILES string   [H][C@@]12CC[C@@]3([H])[C@](C)(CO)[C@H](O)CC[C@]3(C)[C@]14CC[C@](O)(CO)[C@]([H])(C2)C4
InChI   1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
InChI key   NOFOAYPPHIUXJR-APNQCZIXSA-N
Gene Information   human ... POLA1(5422), POLD1(5424), POLG(5428)

Description

Packaging

1, 5, 10 mg in glass bottle

Biochem/physiol Actions

Aphidicolin is an antibiotic, a potent antiviral and antimitotic agent and DNA polymerase inhibitor.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Caution

Estimated shelf-life is two years. For optimal stability, it should be protected from light and stored desiccated.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
PB9185000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Clinical, Diseases, Ligands, Neurodegenerative Diseases

Discover Bioactive Small Molecules for Cell Cycle Research

In proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during t...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Cell division, Cell proliferation, DNA replication, Diseases, Genetic

Peer-Reviewed Papers
15

References

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