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A1276 Sigma

Amastatin hydrochloride hydrate

≥97% (HPLC)

Synonym: (2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp hydrochloride hydrate

  • CAS Number 100938-10-1

  • Empirical Formula (Hill Notation) C21H38N4O8 · HCl · xH2O

  • Molecular Weight 511.01 (anhydrous basis)

  •  Beilstein/REAXYS Number 8888370

  •  MDL number MFCD00150636

  •  PubChem Substance ID 24890521

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Description

General description

Chemical structure: peptide

Biochem/physiol Actions

It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.

Effective concentration: 1-10 μM.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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