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A129 Sigma-Aldrich

Amoxapine

Synonym: 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine

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Properties

Related Categories A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
Quality Level   100
solubility   methanol: soluble
originator   Wyeth
SMILES string   Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1
InChI   1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
InChI key   QWGDMFLQWFTERH-UHFFFAOYSA-N
Gene Information   human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)

Description

Biochem/physiol Actions

Tricyclic antidepressant; inhibits uptake of norepinephrine; inhibits 5-HT2 serotonergic receptors.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A129.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
HQ4025500
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Piperazines - Aldrich ChemFiles 2005, 5.5, 1.

Sigma-Aldrich is pleased to offer the third installment of our Privileged Structures ChemFiles. This piece will focus on the piperazine scaffold. We will discuss application data, Sigma-Aldrich build...
Aldrich ChemFiles 2005, 5.5, 1.
Keywords: Anti-depressants, Antifungals, Antivirals, Building blocks, Medicinal chemistry, Metabolism, Organic synthesis, Pharmaceutical

Peer-Reviewed Papers
15

References

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